News Worms
News Worms

New medicine a happy news for heart patients

New medicine a happy news for heart patients

Inhibiting the protein can cause the level of LDL, or "bad" cholesterol, to tumble dramatically to unheard-of levels - from 92 milligrams per deciliter to 30 milligrams. After a follow-up period of around two years, it showed that the risk of heart attack, stroke and coronary revascularisation was cut by 27%, 21% and 22%, respectively. All of them were already receiving statin therapy.

Patients either took statins alone, or took Repatha - also known as evolocumab - alongside their statins.

The upshot? The data showed that the lower LDL goes, the lower CV risks go, and extremely low LDL levels aren't unsafe. But the evidence of a benefit is strong enough that he will discuss the drug as an option with his patients, he adds.

FOURIER is the first outcomes trial to read out for the PCSK9 class. Sanofi and Regeneron are conducting their own study, dubbed ODYSSEY, to test Praluent's cardiovascular benefit. As a result, manufacturers decided to make a clinical trial, and they presented the results at the American College of Cardiology meeting held last Friday.

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An innovative new drug can prevent heart attacks and strokes by cutting bad cholesterol to unprecedented levels, doctors say.

While diet guides and medical textbooks aimed at the general reader aim to lower cholesterol, there is a difference, with total cholesterol, between "good" and "bad" cholesterol. "The open question was, 'Does this way of lowering [cholesterol] reduce risk of coronary heart disease, '" says Sekar Kathiresan, a cardiologist at the Massachusetts General Hospital in Boston and the Broad Institute in Cambridge, Massachusetts, who was not involved in the study. That trial is expected to read out sometime this year and will give a better sense of how high of a bar Amgen has set with Repatha. Some payer coverage decisions come with qualifications like a requirement that patients meet specific criteria or try other treatments first. A small percentage of patients can't tolerate statins and Repatha could help them in keeping their cholesterol level in control.

Many doctors said that the results from the medicine were a major achievement in the heart conditions.

A second study of another PCSK9 inhibitor, bococizumab, was much less successful and was terminated, they reported Friday.

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For the study, the team looked at the protective effect of evolocumab on 27,564 patients, aged 40-85 from 49 countries, with a history of atherosclerotic vascular disease, who were already taking statins to reduce their cholesterol.

"A promising new approach is blocking the action of PCSK9, a molecule which reduces the breakdown of LDL-cholesterol in the liver". It also blocks the capacity of the PCSK9, so there is a high number of receptors to break up cholesterol LDL. The primary endpoint was the change from baseline score of spatial working memory strategy index of executive function in evolocumab and placebo groups.

Result of study involving Repatha were shared on Friday at a meeting of the American College of Cardiology.

"We did not find evidence for decline in neurocognitive function after almost two years od treatment with evolocumab using a dedicated series of neuropsychological tests".

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"There has always been a debate that low LDL cholesterol levels could lead to negative effects on memory or other cognitive functions", saidRobert P. Giugliano, M.D., S.M., Brigham and Women's Hospital, Boston and lead study investigator.


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