News Worms
News Worms

New Technology For Flu Vaccination On The Horizon

New Technology For Flu Vaccination On The Horizon

"One of the main goals of developing the microneedle patch technology was to make vaccines accessible to more people".

Rouphael added the participants who used the patch liked it.

In fact more than 70% of participants said they would prefer to use in the future compared to visiting the doctor.

The new clinical trial is a preliminary study, so more research is needed before the microneedle patch could be made available to the general public.

The study, published online June 27, 2017, in The Lancet, was led by Nadine Rouphael, M.D., associate professor of medicine and Mark J. Mulligan, M.D., distinguished professor of medicine, Emory University School of Medicine, in collaboration with Mark R. Prausnitz, Ph.D., Regents Professor and J. Erskine Love Chair in Chemical and Biomolecular Engineering, Georgia Institute of Technology. Microneedle patches also overcome needle phobia issues, which will significantly increase uptake. "It has to be a small volume, because you know, the patches are not that big; they can't hold that much", Morse said.

Prausnitz and several other Georgia Tech researchers are inventors of the microneedle patch technology used in this study and have ownership interest in Micron Biomedical.

There were no adverse effects either, apart from some faint redness of the skin around the patch site, and some mild itching for a couple of days. The system delivers vaccine antigens across the stratum corneum directly into the skin epidermis and dermis.

In principle, you don't need an inch-long hypodermic needle to puncture a barrier that's thinner than a hair. It showed that the microneedle patch can produce antibody responses similar to regular flu shots. The patch could be kept on a shelf at up to 40 degrees, when most vaccines had to be stored at between 2 and 8 degrees or they would lose their potency. Some of the 100 volunteers got the regular shot in the arm, while others applied the microneedle patch to their wrist for 20 minutes. None of the participants had received a flu vaccine during the previous influenza season. They were randomly separated into four groups before being treated. No differences were found between the patients who self-administered the patch and those who had a nurse stick it on.

In the first human trial of the patch, involving 100 people, the patch was found to be just as effective as generating immunity for 12 months, and was preferred by the vast majority of those taking part.

Thousands got the flu this season in what was one of the deadliest in almost a decade.

Nearly no one reported feeling any pain from the patch's microneedles, but some participants developed some mild skin redness and irritation around the injection site. This type of reaction is normal and can be explained as the body's response to receiving the vaccine, Rouphael said.

"Dissolvable microneedle patches could potentially simplify the delivery of influenza vaccines", she says.

Getting an injection is on the bottom of everybody's list of favorite things, but now a more bearable alternative is another step closer to reality.

When pressed into the skin, the tiny needles dissolve, carrying vaccine into the skin.


editors' picks

June 29, 2017
Brendan Dassey wins in federal appeals court
Lawyers have vowed to fight to free Dassey, whose case garnered worldwide attention after featuring in the popular Netflix series. The state said it plans to appeal Thursday's ruling to the entire panel of judges on the US 7th Circuit Court of Appeals .

June 29, 2017
Uber Keeps Bleeding Executives: Travis Kalanick Resigns As CEO At Shareholders' Request
Kalanick was in Chicago Tuesday night when he received word that investors wanted him out, the New York Times reported . That said, Kalanick, who's said to control a majority of the votings rights at Uber, will keep his board seat.

June 29, 2017
Jaguar Unleashes Its Most Powerful Production Car Ever
And will you be giving them first refusal on Project 8? "Project 8, for me, is that concept taken to its logical extreme". The XE SV Project 8 is powered by a monstrous supercharged 5.0-liter V8, in an absolutely new state of tune.

June 29, 2017
Paul Manafort registers as foreign agent
Manafort had been consulting in Ukraine for Yanukovych and the Party of Regions at least as far back as 2005. When the two lobbying firms registered , Maloni had said at that time that Manafort would as well.

June 29, 2017
Google News finally gets a much needed refreshed design
The latter is again based on your interests and creates a "mini news feed" of articles that might be of interest to you. Videos and tweets have gained prominence, being labelled with "most referenced" and placed in related coverage cards.

June 29, 2017
President Trump singles out Irish journalist to comment on her 'nice smile'
She described the encounter as a " bizarre moment". "Where are you from, come here, come here, where are you from?" he then asks Perry.

June 28, 2017
Lockdown lifted at military post; no injuries reported
An active shooter drill was planned for Wednesday at the arsenal, but officials said today's lockdown was not part of the drill. During a news conference just after noon, Redstone spokesman Chris Colster said "We aren't sure what triggered this".

June 28, 2017
Colombia takes big step to peace as rebels lay down guns
The militant rebel group has been involved in drug trafficking, kidnapping and other illicit activity to fund its insurgency. The monitors said they had also found and emptied 77 out of the Farc's 900 arms caches hidden around the countryside.

June 28, 2017
Prime Minister Narendra Modi Addresses Indian Community In Netherlands
Pakistan and terrorism follow the reference to the Indo-Pacific in the joint statement. Indo-Dutch economic engagement is a win-win proposition.

June 28, 2017
Ansel Elgort studied hard to do sign language justice in Baby Driver
Indeed, beneath all the designer violence and pounding music, Baby Driver's good natured to the point of being nearly quaint. For that one, they put the camera in where Lily [James] would have been sitting when they filmed me drifting out of it.